Introduction Polymers are large molecules composed of repeating structural units (monomers) connected by covalent bonds. These macromolecules can be natural (e.g., proteins, polysaccharides) or synthetic (e.g., polyethylene, polylactic acid). The versatility of polymers, such as their ability to modify drug release profiles, has made them central to the development of …
DeepakRajput 
Physicochemical and Biological Properties of Drugs Relevant to Controlled Release Formulations
Controlled release formulations are designed to maintain therapeutic drug levels for an extended period. For successful formulation, the physicochemical and biological properties of the drug must meet specific criteria. I. Physicochemical Properties of Drugs 1. Aqueous Solubility: Drugs should have moderate solubility (not too high or too low). Relevance: Low …
Approaches to design-controlled release formulations: Based on diffusion, dissolution and ion exchange principles
Controlled release formulations can be designed using various mechanisms that regulate drug release. Three primary principles often employed are diffusion, dissolution, and ion exchange. Each approach involves different methodologies and is tailored to achieve a specific release profile. 1. Diffusion-Based Systems In diffusion-controlled systems, the drug release occurs as the …
Controlled drug delivery systems (CDDS): Definition, Terminology, Rationale, Advantages and disadvantages
Controlled drug delivery systems (CDDS) are advanced systems designed to deliver therapeutic agents at a predetermined rate, locally or systemically, for a specified period. The goal is to achieve an optimized therapeutic response while minimizing side effects. This technology addresses the limitations of conventional drug delivery systems, such as fluctuating …
