Renal Clearance

Factors Affecting Renal Excretion of Drugs

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Factors Affecting Renal Excretion of Drugs Renal excretion represents one of the most crucial pathways through which the body eliminates drugs and their metabolites. The efficiency of this system is influenced by a variety of physiological, biochemical, and physicochemical factors. The kidneys employ three synchronized mechanisms—glomerular filtration, tubular secretion, and tubular reabsorption—to determine the rate … Read more

Kinetics of Elimination

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1. Introduction of Kinetics of Elimination Drug elimination is a vital pharmacokinetic process that refers to the irreversible removal of active drug molecules from the body. It primarily occurs through metabolism (biotransformation) and excretion. Together with absorption and distribution, elimination determines the duration and intensity of a drug’s pharmacological action. Understanding the kinetics of elimination … Read more