Phenoxybenzamine: Mechanism, Uses, Side effects

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Screenshot 2023 12 28 132808 Phenoxybenzamine: Mechanism, Uses, Side effects

Phenoxybenzamine is a medication classified as an alpha-adrenergic antagonist, specifically an irreversible alpha-blocker. It is used primarily to treat conditions associated with excessive sympathetic nervous system activity, such as pheochromocytoma, a rare adrenal tumor that releases high levels of catecholamines, leading to severe hypertension. Here are key points about phenoxybenzamine: Mechanism of Action Phenoxybenzamine irreversibly … Read more

Phentolamine: Mechanism, Uses, Side effects

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Screenshot 2023 12 28 101008 Phentolamine: Mechanism, Uses, Side effects

Phentolamine is a medication classified as an alpha-adrenergic antagonist, specifically an alpha-blocker. It acts by blocking the effects of norepinephrine and other similar neurotransmitters at alpha-adrenergic receptors. Phentolamine is a non-selective alpha-blocker, meaning it blocks both alpha-1 and alpha-2 receptors. Here are key points about phentolamine: 1. Mechanism of Action Phentolamine blocks the action of … Read more

Tolazoline: Mechanism, Uses, Side effects

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Screenshot 2023 12 28 100512 Tolazoline: Mechanism, Uses, Side effects

Tolazoline is a medication that belongs to the class of drugs known as alpha-adrenergic blockers. It is primarily used as a vasodilator, which relaxes and widens blood vessels. This vasodilatory effect is attributed to its ability to block alpha-adrenergic receptors. Here are some key points about tolazoline: Mechanism of Action Tolazoline acts as a non-selective … Read more

Adrenergic antagonists/adrenergic blockers/adrenergic receptor antagonists

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Screenshot 2023 12 28 095820 Adrenergic antagonists/adrenergic blockers/adrenergic receptor antagonists

Adrenergic antagonists, also known as adrenergic blockers or adrenergic receptor antagonists, are a class of drugs that interfere with the actions of the sympathetic nervous system, specifically by blocking the effects of neurotransmitters like norepinephrine and epinephrine (adrenaline) at adrenergic receptors. These receptors are found throughout the body and are crucial in regulating various physiological … Read more

Filtration : Objective, Application, Equations

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Screenshot 2023 12 27 183729 Filtration : Objective, Application, Equations

Filtration is the process wherein a filter medium separates a heterogeneous mixture of fluid and solid particles. The filter medium allows the passage of fluid but retains the solid particles. The process retains oversized solids in the fluid, but it does not complete the separation, as the filtrate may contaminate with solid particles smaller in … Read more

Triple Roller Mill: Principle, Construction, Working

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Screenshot 2023 12 27 182413 Triple Roller Mill: Principle, Construction, Working

A triple roller mill is used to mix semisolids while preparing ointments, creams, pill masses, wet mass for making granules, etc. Principle The material experiences a high shear developed by the differential speed and the narrow space between the rollers. Under the influence of this shear, aggregates, and particles get crushed, and the drug gets … Read more

Silverson Mixer Homogeniser: Principle, Construction, Working

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Screenshot 2023 12 27 180331 Silverson Mixer Homogeniser: Principle, Construction, Working

Silverson emulsifiers mix or homogenize coarse particles in the emulsion and suspension, reducing them to fine particles. Its capacity ranges from 1 ml to 12 lt, and its ability to mix in-line with flow rates is up to 20 lt/min. Principle Silverson emulsifier works on the principle of shearing forces and turbulence produced by the … Read more

Turbine Mixer: Construction, Working, Application

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Screenshot 2023 12 27 175034 Turbine Mixer: Construction, Working, Application

Turbines are mechanical devices that mix different fluids with blades and impellers. Turbines are used for mixing high viscosity liquids because of the greater shear forces produced by them than the propellers. They are used especially for the preparation of emulsion. For preventing vortex formation, baffles are often used. Construction ¨ Turbines consist of a … Read more

Double Cone Blender: Principle, Working, Application, Merits and Demerits

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Screenshot 2023 12 27 151612 Double Cone Blender: Principle, Working, Application, Merits and Demerits

A Double cone blender is a competent and versatile machine used for uniform blending of granules and dry powders. It is made up of stainless steel. It is available in various working capacities ranging from 5 – 500 liters. Principle A double-cone blender produces a homogeneous solid-solid mixture. This equipment involves axial mixing as the … Read more

Mixing: Objectives, Application, Equipments

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Screenshot 2023 12 27 145540 Mixing: Objectives, Application, Equipments

Mixing is among the most important unit operation processes in many industries. It involves the mixing of solids, liquids, or gases having two or more than two components. Mixing is the process where two or more ingredients are treated so that every particle of any one ingredient lies as near as possible to the particle … Read more