Definition of Microparticles Microparticles are small, solid particles typically ranging from 1 to 1000 microns in diameter. These particles can be composed of a variety of materials such as polymers, lipids, proteins, or ceramics. Microparticles are often used in drug delivery systems, biomedical applications, and other industrial purposes. The core function of microparticles is to … Read more
Definition of Microcapsules Microcapsules are small, spherical particles that consist of a core material (typically an active ingredient like a drug, nutrient, or bioactive compound) surrounded by a protective shell or coating. The core material can be liquid, solid, or gas, and the shell is typically made from biocompatible materials, such as polymers, lipids, or … Read more
Definition of Microspheres Microspheres are small, spherical particles typically ranging from 1 to 1000 microns in size. They are commonly used in drug delivery systems, diagnostics, and other pharmaceutical and biomedical applications. Microspheres are made from various materials, including polymers, lipids, and ceramics. These particles can encapsulate active ingredients such as drugs, enzymes, or other … Read more
Microencapsulation is a process where active substances (such as drugs, nutrients, or bioactive compounds) are enclosed within a protective coating or shell, typically in the micron or sub-micron size range (1 to 1000 microns). The primary goal is to protect the active ingredient from environmental factors (e.g., light, moisture, air) or to control the release … Read more
1. Introduction A drug distribution system in a hospital is the organized process by which medications are procured, stored, prepared, and delivered to patients with the primary aim of ensuring rational, safe, and timely drug therapy. This system plays a central role in the hospital’s therapeutic and administrative activities. The hospital pharmacy serves as the … Read more
Introduction Polymers are large molecules composed of repeating structural units (monomers) connected by covalent bonds. These macromolecules can be natural (e.g., proteins, polysaccharides) or synthetic (e.g., polyethylene, polylactic acid). The versatility of polymers, such as their ability to modify drug release profiles, has made them central to the development of advanced drug delivery systems, particularly … Read more
Controlled release formulations are designed to maintain therapeutic drug levels for an extended period. For successful formulation, the physicochemical and biological properties of the drug must meet specific criteria. I. Physicochemical Properties of Drugs 1. Aqueous Solubility: Drugs should have moderate solubility (not too high or too low). Relevance: Low solubility can limit the drug’s … Read more
Controlled release formulations can be designed using various mechanisms that regulate drug release. Three primary principles often employed are diffusion, dissolution, and ion exchange. Each approach involves different methodologies and is tailored to achieve a specific release profile. Controlled release formulations 1. Diffusion-Based Systems Diffusion-controlled drug delivery systems are among the most widely employed strategies … Read more
Controlled drug delivery systems (CDDS) are advanced systems designed to deliver therapeutic agents at a predetermined rate, locally or systemically, for a specified period. The goal is to achieve an optimized therapeutic response while minimizing side effects. This technology addresses the limitations of conventional drug delivery systems, such as fluctuating plasma drug levels and the … Read more
Maintaining accurate and up-to-date records in retail and wholesale drug stores is a legal and ethical requirement. It ensures the proper functioning of the pharmacy, compliance with regulatory guidelines, and safety in drug distribution. Record-keeping also facilitates accountability and traceability in the pharmaceutical supply chain. 1. Importance of Record Maintenance Legal Compliance: Adherence to the … Read more
