Aim: Study of Local Anesthetics by Different Methods References: Background and Principle: Local anesthetics (LAs) are drugs that cause reversible loss of sensation in a localized area of the body without affecting consciousness. They act mainly by blocking voltage-gated sodium channels in the neuronal cell membrane, preventing nerve impulse conduction. Their effectiveness can be studied … Read more
Aim: Study of anxiolytic activity of drugs using rats/mice References: Objective:To evaluate the anxiolytic effects of drugs using common behavioral assays in rats/mice. Materials and Methods: Materials: Method 1: Elevated Plus Maze (EPM) Sample Result Table: Group Time in Open Arms (s) Time in Closed Arms (s) Open Arm Entries Closed Arm Entries Control 50 … Read more
Aim: Study of stereotype and anti-catatonic activity of drugs on rats/mice References: Objective:To evaluate the stereotype and anti-catatonic activity of drugs in rats/mice. Materials and Methods: Materials: Method for Stereotype Activity: Sample Result Table: Time (minutes) Stereotyped Behavior Score Observations Control Group Test Group Baseline 0 0 15 1 3 30 1 4 60 2 … Read more
Aim: Anticonvulsant effect of drugs by MES and PTZ method References Objective To evaluate the effectiveness of anticonvulsant drugs by observing their ability to suppress seizures in two distinct animal models: MES and PTZ-induced seizures. Materials and Methods Materials A. MES (Maximal Electroshock Seizure) Method Procedure: Sample Results Table: Group Tonic Flexion (s) Tonic Extension … Read more
Aim: Effect of drugs on locomotor activity using Actophotometer References Objective To investigate the central nervous system (CNS) activity—stimulant or depressant—of selected drugs by quantifying locomotor activity in rodents using an actophotometer. Materials Required Experimental Procedure 1. Animal Preparation: Acclimate animals to the laboratory environment for at least one hour prior to the experiment.Handle animals … Read more
Aim: Effects of skeletal muscle relaxants using Rota-rod apparatus References Objective To evaluate the impact of skeletal muscle relaxant drugs on motor performance and coordination in rodents using the Rota-Rod apparatus. Materials Required Experimental Methodology 1. Animal Preparation: Acclimate animals to the lab environment for at least 1 hour before testing.Handle rodents gently to minimize … Read more
Aim: Effects of Drugs on Rabbit Eye References Objective To study and compare the ocular effects of various drugs, including changes in pupil size, intraocular pressure, and corneal reflex in rabbits. Materials Required Experimental Methodology 1. Animal Preparation: Acclimate rabbits to the lab environment for at least 1 hour.Place each rabbit in a comfortable restraining … Read more
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