Introduction to Autacoids The word autacoid originates from the Greek words “autos” (self) and “akos” (remedy or healing). Literally, autacoids mean “self-remedy” or “self-healing” substances. In pharmacology, autacoids are defined as biologically active chemical substances produced by the body that exert local effects, generally close to the site of their synthesis, and are subsequently metabolized … Read more
Antihistaminic agents, commonly referred to as antihistamines, are drugs that counteract the effects of histamine, a vital biogenic amine involved in various physiological and pathological processes. These agents are primarily used to manage allergic conditions, gastrointestinal issues, and certain central nervous system disorders. Below is a comprehensive exploration of histamine, its receptors, and their distribution … Read more
Inflammation is regulated by a complex network of chemical mediators that orchestrate the response to injury or infection. These mediators originate from various cells and tissues and include vasoactive amines, lipid mediators, cytokines, chemokines, and other small molecules. They play roles in vasodilation, increased vascular permeability, leukocyte recruitment, and other aspects of the inflammatory response. … Read more
Histamine is a biogenic amine, a compound derived from amino acids, that serves as a signaling molecule and neurotransmitter in the body. It is produced and stored in various cells, particularly mast cells and basophils, which are immune system components. When released, histamine plays a key role in several physiological processes, including inflammation, allergic reactions, … Read more
Autocoids, short for “autonomous mediators,” refer to a diverse group of naturally occurring substances within the body that act locally to regulate physiological functions. These substances are produced in small quantities and exert their effects near the site of synthesis. Autocoids play essential roles in maintaining homeostasis and mediating various physiological processes. Examples of autocoids … Read more
